課程資訊
課程名稱
環境衛生風險評估
Risk Assessment for Environmental Health 
開課學期
99-2 
授課對象
公共衛生學院  環境衛生研究所  
授課教師
林嘉明 
課號
EH7012 
課程識別碼
844 M1150 
班次
 
學分
全/半年
半年 
必/選修
選修 
上課時間
星期三3,4(10:20~12:10) 
上課地點
公衛201 
備註
總人數上限:30人 
Ceiba 課程網頁
http://ceiba.ntu.edu.tw/992RAEH 
課程簡介影片
 
核心能力關聯
本課程尚未建立核心能力關連
課程大綱
為確保您我的權利,請尊重智慧財產權及不得非法影印
課程概述

上課教室改至701

教學目標:本課程透過閱讀、討論、練習等方式,使學生熟悉經由環境與職業暴露化學有害物的健康風險評估,尤其強調方法論與實務應用。

99學年度第2學期(23/02/2011-22/06/2011)環境衛生風險評估課程大綱
課程編號:環境衛生風險評估 844M1150
授課教師:林嘉明 TEL:02-33668103
課程助教:徐仕哲

日期 內容* 備註*
2/23 Introduction(Risk, health risk assessment, risk management)
3/02 Chemical hazards and risk acceptability
3/09 Exposure, exposure assessment, exposure scenario and dose
3/16 Quantifying exposure dose
3/23 Calculation of human dose rate and dose from human and animal studies
3/30 Quantization of response; Calculation of excess risk
4/06 Holiday
4/13 Excess risk and dose: Tolerance distribution models
4/20 Midterm examination
4/27 Excess risk and dose: Mechanistic models
5/04 Life time risk estimate for sub-experimental dose range
5/11 Acceptable concentration
5/18 Acceptable concentrations-risk analysis method for non-threshold
toxicants
5/25 Acceptable concentrations-safety factor (uncertainty factor) method
for threshold toxicants
6/01 Acceptable concentrations (Benchmark dose derived reference
concentration, RfC)-benchmark dose method for threshold toxicants
6/08 Application of software to health risk assessment —Monte Carlo
Simulation; Demonstration of a case study
6/15 Plausibility of calculating excess risk; Planning risk assessment; Demonstration of case studies
6/23 Final examination


參考書籍
1. William H. Hallenbeck: Quantitative risk assessment for
environmental and occupational health (2nd Edition), Lewis
Publisher, New York, 1993
2. Jack E. Daugherty: Assessment of chemical exposure, calculation
methods for environmental professionals, Lewis Publishers, New
York, 1998
 

課程目標
本課程討論化學危害經由環境介質影響人類健康的風險;解釋風險的意義;說明量化風險的過程(危害鑑定、劑量效應分析、暴露評估、風險描述);並且議論風險量化過程所牽涉的概念、術語、方法學、模式及應用軟體。全程以講述及舉例練習的方式進行。

1.讓學生瞭解風險的技術面意義;
2.讓學生有能力量化暴露劑量;
3.讓學生有能力分析劑量與風險的
關係;
4.讓學生有能力推估及描述終生暴
露低劑量化學物的風險;
5.讓學生有能力推算風險管理上需
要的容許暴露濃度值。
 
課程要求
 
預期每週課後學習時數
 
Office Hours
 
指定閱讀
 
參考書目
1. William H. Hallenbeck: Quantitative risk assessment for
environmental and occupational health (2nd Edition), Lewis
Publishers, New York, 1993
2. Jack E.Daugherty: Assessment of chemical exposures,
calculation methods for environmental professionals, Lewis
Publishers, New York, 1998
3. Principles for the assessment of risks to human health from exposure to
chemicals, Geneva: World Health Organization, 1999
4. Joseph V. Rodricks: Calculated risks:the toxicity and human health risks of
chemicals in our environment, Cambridge; New York: Cambridge University Press,
2007
 
評量方式
(僅供參考)
 
No.
項目
百分比
說明
1. 
期末報告 
100% 
繳交時間為第16~17週 請注意Deadline為6/15 
2. 
期末考 
100% 
 
3. 
期中考 
100% 
 
4. 
平時作業 
100% 
 
 
課程進度
週次
日期
單元主題
第1週
2/23  Introduction (Risk, health risk assessment, risk management, risk communication, data availability) 
第2週
3/02  Chemical hazards and risk acceptability 
第3週
3/09  Exposure, exposure assessment, exposure scenario, and dose 
第4週
3/16  Exposure dose and dose rates 
第5週
3/23  Calculation of human dose rate and dose from human and animal studies 
第6週
3/30  Quantization of response 
第7週
4/06  Calculation of excess risk 
第8週
4/13  Excess risk and dose: Tolerance distribution models 
第9週
4/20  Midterm examination 
第10週
4/27  Excess risk and dose: Mechanistic models 
第11週
5/04  Life time risk estimate for sub-experimental dose range 
第12週
5/11  Acceptable concentration 
第13週
5/18  Acceptable concentrations-risk analysis method for non-threshold  
第14週
5/25  Acceptable concentrations-safety factor (uncertainty factor) method for threshold toxicants 
第15週
6/01  Acceptable concentrations (Benchmark dose derived reference concentration, RfC)-benchmark dose method for threshold toxicants 
第16週
6/08  Application of software to health risk assessment –Monte Carlo Simulation 
第17週
6/15  Plausibility of calculating excess risk; Planning risk assessment; Demonstration of case studies 
第18週
06/22  Final examination